Silver Sulphadiazine 1% is used in the treatment of burns. It is applied on the burnt skin from getting infected.
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Burna 1% Cream contains Silver sulphadiazine, a member of the Sulfonamides group of medicines. It is used for the prevention and treatment of infections in burn wounds, leg ulcers, pressure sores, and finger-tip injuries caused by sensitive microorganisms.
However, Burna 1% Cream is not recommended for individuals who are allergic to silver sulphadiazine/sulphonamide, cetyl alcohol, or propylene glycol.
Before using Burna 1% Cream, inform your doctor if you have glucose-6-phosphate dehydrogenase deficiency (a genetic disorder affecting red blood cells), lung problems, kidney problems, or liver problems.
The cream should be used with caution during pregnancy and breastfeeding, only if necessary.
It is not suitable for premature infants or newborns below 3 months of age, and elderly patients should use it with caution after consulting a doctor.
The most common side effects of Burna 1% Cream include leukopenia (low white blood cell count), skin reactions at the application site (such as burning or rash), and itching. If any of these symptoms worsen, consult your doctor.
There is no known interaction between Burna 1% Cream and alcohol.
There is no safety information available on the use of Burna 1% Cream during pregnancy. Do not use it unless advised by a doctor.
Burna 1% Cream should not be used by a lactating mother due to a lack of safety information on the use of the product in lactating women. It should not be applied to the breast or areas near the breast of a breastfeeding mother as there can be chances of ingestion by a breastfed infant.
Burna 1% Cream is used externally on the skin and is less likely to influence the driving ability of an individual.
Burna 1% Cream should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before applying Burna 1% Cream.
Burna 1% Cream should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before applying Burna 1% Cream.
Burna 1% Cream works by inhibiting the bacterial enzyme dihydropteroate synthetase (the enzyme responsible for folic acid synthesis in bacteria) which leads to the blockade of DNA synthesis in bacteria resulting in the prevention and synthesis of bacterial growth in burn wounds, leg ulcers, and/or pressure sores in affected individuals.
Silver sulfadiazine's antibacterial activity mechanism is not fully understood. However, when the drug is applied to the affected area, it induces secondary changes in the bacterial cell membrane. These changes include twisting and elongation of the cell, weakening the cell wall layer, and reducing the viability of susceptible strains.
The silver sulfadiazine molecule dissociates, and the silver component binds to the bacterial cells. Upon entering the bacterial cell wall, the silver component attaches to the bacterial deoxyribonucleic acid (DNA), preventing bacterial cell replication. Mammalian cells contain approximately 100 times more DNA than bacterial cells. The ratio of silver sulfadiazine to bacterial DNA is believed to be high enough to inhibit bacterial division, while the corresponding ratio to epithelial DNA is low enough not to impede epithelial cell regeneration.
The sulfadiazine moiety of the drug also provides bacteriostatic activity against susceptible organisms. In summary, silver sulfadiazine's mechanism of action involves interfering with bacterial cell division through interactions with bacterial DNA, while also exerting a bacteriostatic effect against sensitive bacteria.
Topical/Cutaneous Treatment and prophylaxis of infection in severe burns:
Child Dose:
2 months (1% cream): Apply the cream onto the affected area 1-2 times a day.
For burns:
For hand burns:
For leg ulcers/pressure sores:
Enzymatic debriding agents: The use of enzymatic debriding agents may not be suitable when used together with Silver sulfadiazine, as it could potentially inactivate these agents.
Oral hypoglycemic agents and phenytoin: In patients with large-area burns, the serum levels of sulfadiazine may reach therapeutic levels, leading to a possible potentiation of the effects of oral hypoglycemic agents and phenytoin. Therefore, it is advisable to monitor the blood levels of these medications in such patients.
Cimetidine: Co-administration of Cimetidine with Silver sulfadiazine in patients with large-area burns may increase the incidence of leukopenia (a decrease in white blood cells). Caution should be exercised when using these medications together in such cases.
Pregnancy Category B. This drug should be used during pregnancy only if clearly justified, especially in pregnant women approaching or at term. It is not known whether Silver Sulfadiazine is excreted in human milk. A decision should be made, whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use Safety and effectiveness in pediatric patients have not been established.
Store in a cool and dry place away from direct sunlight. Keep it out of the reach of children and pets.
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